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Food for thought: How cell adhesion coordinates nutrient sensing by Hellyeh Hamidi et al.
Cell adhesion controls cell survival and proliferation via multiple mechanisms. Rabanal-Ruiz et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202004010) demonstrate that focal adhesions are key signaling hubs…
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A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance by Hussein Al-Akhrass et al.
Current evidence indicates that resistance to the tyrosine kinase-type cell surface receptor (HER2)-targeted therapies is frequently associated with HER3 and active signaling via HER2-HER3 dimers,…
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Erratum: Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts by Martina Lerche et al.
[This corrects the article DOI: 10.1016/j.isci.2020.100907.].
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Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting by James Ronald William Conway et al.
Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been…
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Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels by Nuria Barber-Pérez et al.
Fibrillar adhesions are important structural and adhesive components in fibroblasts, and are required for fibronectin fibrillogenesis. While nascent and focal adhesions are known to respond…
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MASTL promotes cell contractility and motility through kinase-independent signaling by Maria Emilia Taskinen et al.
Microtubule-associated serine/threonine-protein kinase-like (MASTL) is a mitosis-accelerating kinase with emerging roles in cancer progression. However, possible cell cycle-independent mechanisms behind its oncogenicity remain ambiguous. Here,…
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Fluctuation-Based Super-Resolution Traction Force Microscopy by Aki Stubb et al.
Cellular mechanics play a crucial role in tissue homeostasis and are often misregulated in disease. Traction force microscopy is one of the key methods that…
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Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts by Martina Lerche et al.
The link between integrin activity regulation and cellular mechanosensing of tissue rigidity, especially on different extracellular matrix ligands, remains poorly understood. Here, we find that…
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Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells by Aki Stubb et al.
While it is clear that key transcriptional programmes are important for maintaining pluripotency, the requirement for cell adhesion to the extracellular matrix remains poorly defined.…
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Filopodia Quantification Using FiloQuant by Guillaume Jacquemet et al.
Filopodia are fingerlike membrane protrusions that are extended by cells in vitro and in vivo. Due to important roles in sensing the extracellular microenvironment, filopodia…
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A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites by Barry McCormick et al.
Neutrophils are abundant circulating leukocytes that are rapidly recruited to sites of inflammation in an integrin-dependent fashion. Contrasting with the well-characterized regulation of integrin activation,…
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Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes by Laura Kähäri et al.
Lymph nodes (LNs) filter lymph to mount effective immune responses. Small soluble lymph-borne molecules from the periphery enter the draining LNs via a reticular conduit…
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Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops by Kamila Czechowska et al.
No abstract
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Integrins as biomechanical sensors of the microenvironment by Jenny Z Kechagia et al.
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as…
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2 by Mika Pietilä et al.
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many…
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GGA2 and RAB13 promote activity-dependent β1-integrin recycling by Pranshu Sahgal et al.
β1-integrins mediate cell-matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here,…
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68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice by Riikka Siitonen et al.
Shank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of nuclear factor κ-light-chain enhancer of activated B cells…
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Integrin signaling and mechanotransduction in regulation of somatic stem cells by Aleksi Isomursu et al.
Somatic stem cells are characterized by their capacity for self-renewal and differentiation, making them integral for normal tissue homeostasis. Different stem cell functions are strongly…
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Author Correction: Every step of the way: integrins in cancer progression and metastasis by Hellyeh Hamidi et al.
In the originally published article, pertuzumab was incorrectly described as an anti-PI3K therapy in the section ‘Integrins in anticancer therapy’. The sentence should read ‘In…
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Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability by Guillaume Jacquemet et al.
Filopodia are adhesive cellular protrusions specialized in the detection of extracellular matrix (ECM)-derived cues. Although ECM engagement at focal adhesions is known to trigger the…
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