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Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2018 Conference Workshops by Kamila Czechowska et al.
No abstract
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Integrins as biomechanical sensors of the microenvironment by Jenny Z Kechagia et al.
Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as…
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SORLA regulates endosomal trafficking and oncogenic fitness of HER2 by Mika Pietilä et al.
The human epidermal growth factor receptor 2 (HER2) is an oncogene targeted by several kinase inhibitors and therapeutic antibodies. While the endosomal trafficking of many…
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GGA2 and RAB13 promote activity-dependent β1-integrin recycling by Pranshu Sahgal et al.
β1-integrins mediate cell-matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here,…
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68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice by Riikka Siitonen et al.
Shank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of nuclear factor κ-light-chain enhancer of activated B cells…
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Integrin signaling and mechanotransduction in regulation of somatic stem cells by Aleksi Isomursu et al.
Somatic stem cells are characterized by their capacity for self-renewal and differentiation, making them integral for normal tissue homeostasis. Different stem cell functions are strongly…
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Author Correction: Every step of the way: integrins in cancer progression and metastasis by Hellyeh Hamidi et al.
In the originally published article, pertuzumab was incorrectly described as an anti-PI3K therapy in the section ‘Integrins in anticancer therapy’. The sentence should read ‘In…
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Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability by Guillaume Jacquemet et al.
Filopodia are adhesive cellular protrusions specialized in the detection of extracellular matrix (ECM)-derived cues. Although ECM engagement at focal adhesions is known to trigger the…
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Integrin trafficking in cells and tissues by Paulina Moreno-Layseca et al.
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized…
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Editorial overview: Cell architecture: Integrating physics and chemistry in emergent cellular properties by Johanna Ivaska et al.
No abstract
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ProLIF – quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes by Nicola De Franceschi et al.
Integrin transmembrane receptors control a wide range of biological interactions by triggering the assembly of large multiprotein complexes at their cytoplasmic interface. Diverse methods have…
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Every step of the way: integrins in cancer progression and metastasis by Hellyeh Hamidi et al.
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health. Integrins are the main cellular adhesion receptors that through multifaceted roles…
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Targeting β1-integrin inhibits vascular leakage in endotoxemia by Laura Hakanpaa et al.
Loss of endothelial integrity promotes capillary leakage in numerous diseases, including sepsis, but there are no effective therapies for preserving endothelial barrier function. Angiopoietin-2 (ANGPT2)…
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Integrin activity in neuronal connectivity by Johanna Lilja et al.
The formation of correct synaptic structures and neuronal connections is paramount for normal brain development and a functioning adult brain. The integrin family of cell…
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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation by Pirita Pekkonen et al.
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.…
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Mitosis-Resistant Adhesions Provide Molecular Memory to Dividing Cells by Guillaume Jacquemet et al.
During mitosis, animal cells disassemble focal adhesions and round up while remaining attached to the substrata via actin cables and unknown adhesive structures. In this…
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Using xCELLigence RTCA Instrument to Measure Cell Adhesion by Hellyeh Hamidi et al.
Cell adhesion to neighbouring cells and to the underlying extracellular matrix (ECM) is a fundamental requirement for the existence of multicellular organisms. As such, the…
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Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration by Kasper J Mygind et al.
The transmembrane protease ADAM9 is frequently upregulated in human cancers, and it promotes tumour progression in mice. In vitro, ADAM9 regulates cancer cell adhesion and…
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Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment by Riina Kaukonen et al.
2D surfaces offer simple analysis of cells in culture, yet these often yield different cell morphologies and responses from those observed in vivo. Considerable effort…
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Epithelial vimentin plays a functional role in mammary gland development by Emilia Peuhu et al.
In the mammary gland, vimentin intermediate filaments are expressed in stromal cells and in basal epithelial cell populations, including gland-reconstituting mammary stem cells, with largely…
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