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CELL ADHESION AND CANCER LAB

Integrins, matrix, motility and mechanotransduction in cancer

WELCOME TO OUR LAB

We are interested in understanding how integrins contribute to almost every step of cancer progression. Current projects focus on finding novel regulators of integrin activity, and endo/exosomal traffic, and on appreciating the mechanisms controlling tumour-stroma cross-talk, including how cancer cells sense key biophysical cues. We are also investigating signal integration and synergy between integrin regulatory pathways and oncogenic signalling axes in cancer.

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OUR RESEARCH

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Microenvironmental containment of tumors

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Cell adhesion and cancer

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Integrin trafficking

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Receptor tyrosine kinase trafficking

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Biophysical regulation of cancer cells

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Imaging metastasis

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Tools for mechanobiology

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Recent publications

Positive and negative durotaxis – mechanisms and emerging concepts by Mathilde Mathieu et al.

Monday, April 22, 2024

Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration by Michal Dibus et al.

Wednesday, April 17, 2024

Focal adhesions contain three specialized actin nanoscale layers by Reena Kumari et al.

Friday, March 22, 2024

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton by Amy E M Beedle et al.

Tuesday, November 21, 2023

Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration by Aleksi Isomursu et al.

Sunday, November 05, 2023

Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling by James R W Conway et al.

Monday, October 16, 2023

IGFBP2 secretion by mammary adipocytes limits breast cancer invasion by James R W Conway et al.

Wednesday, July 12, 2023

Myosin-X recruits lamellipodin to filopodia tips by Ana Popović et al.

Thursday, March 02, 2023

PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers by Anna Aakula et al.

Saturday, December 03, 2022

Recent news

Johanna receives an ERC Advanced Grant

Tuesday, April 16, 2024

Aleksi defends his PhD thesis

Friday, April 12, 2024

Johanna becomes a member of Academia Europaea!

Friday, June 02, 2023