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Cell Adhesion and Cancer Laboratory

Integrins, matrix, motility and mechanotransduction in cancer

Welcome to our lab

We are interested in understanding how integrins contribute to almost every step of cancer progression. Current projects focus on finding novel regulators of integrin activity, and endo/exosomal traffic, and on appreciating the mechanisms controlling tumour-stroma cross-talk, including how cancer cells sense key biophysical cues. We are also investigating signal integration and synergy between integrin regulatory pathways and oncogenic signalling axes in cancer.

Our research

Microenvironmental containment of tumors

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Cell adhesion and cancer

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Integrin trafficking

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Receptor tyrosine kinase trafficking

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Biophysical regulation of cancer cells

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Imaging metastasis

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Tools for mechanobiology

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The link between cell states and disease

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Recent publications

Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer by Jasmin Kaivola et al.

Monday, October 07, 2024

bioRxiv [Preprint]. 2024 Aug 23:2024.08.22.609159. doi: 10.1101/2024.08.22.6...

The role and regulation of integrins in cell migration and invasion by Megan R Chastney et al.

Monday, September 30, 2024

Nat Rev Mol Cell Biol. 2024 Sep 30. doi: 10.1038/s41580-024-00777-1. Online ...

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers by Johanna Lilja et al.

Thursday, September 12, 2024

Nat Commun. 2024 Sep 12;15(1):8002. doi: 10.1038/s41467-024-52326-1. ABSTRAC...

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity by Neil J Ball et al.

Tuesday, July 16, 2024

J Cell Biol. 2024 Sep 2;223(9):e202310030. doi: 10.1083/jcb.202310030. Epub ...

Positive and negative durotaxis – mechanisms and emerging concepts by Mathilde Mathieu et al.

Monday, April 22, 2024

J Cell Sci. 2024 Apr 15;137(8):jcs261919. doi: 10.1242/jcs.261919. Epub 2024...

Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration by Michal Dibus et al.

Wednesday, April 17, 2024

Curr Opin Cell Biol. 2024 Apr 16;88:102355. doi: 10.1016/j.ceb.2024.102355. ...

Focal adhesions contain three specialized actin nanoscale layers by Reena Kumari et al.

Friday, March 22, 2024

Nat Commun. 2024 Mar 21;15(1):2547. doi: 10.1038/s41467-024-46868-7. ABSTRAC...

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton by Amy E M Beedle et al.

Tuesday, November 21, 2023

bioRxiv. 2023 Nov 11:2023.11.08.566191. doi: 10.1101/2023.11.08.566191. Prep...

Recent news

Nicolas defends his PhD thesis

Monday, September 23, 2024

Congratulations, Nicolas, on successfully defending...

Johanna receives an ERC Advanced Grant

Tuesday, April 16, 2024

We proudly announce that the lab has received an ER...

Aleksi defends his PhD thesis

Friday, April 12, 2024

Congratulations, Aleksi, on successfully defending ...

Johanna becomes a member of Academia Europaea!

Friday, June 02, 2023

Johanna has been appointed a member of the Academia...

Worldwide Cancer Research funding!

Monday, May 29, 2023

We are very excited to receive funding from WWCR to...

Michal is awarded an MSCA postdoc Fellowship

Wednesday, March 01, 2023

Michal received his Marie Skłodowska-Curie Actions ...

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