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Directed cell migration towards softer environments by Aleksi Isomursu et al.
How cells sense tissue stiffness to guide cell migration is a fundamental question in development, fibrosis and cancer. Although durotaxis-cell migration towards increasing substrate stiffness-is…
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MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels by Elisa Närvä et al.
MASTL is a mitotic accelerator with an emerging role in breast cancer progression. However, the mechanisms behind its oncogenicity remain largely unknown. Here, we identify…
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Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates by Swetha Raghuraman et al.
A key behavior observed during morphogenesis, wound healing, and cancer invasion is that of collective and coordinated cellular motion. Hence, understanding the different aspects of…
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Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC by Ana Kasirer-Friede et al.
Platelets form hemostatic plugs to prevent blood loss, and they modulate immunity and inflammation in several ways. A key event during hemostasis is activation of…
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Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Paulina Moreno-Layseca et al.
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the clathrin- and dynamin-independent endocytic pathway (CLIC-GEEC, CG…
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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling by Siiri I Salomaa et al.
Actin-rich cellular protrusions direct versatile biological processes from cancer cell invasion to dendritic spine development. The stability, morphology, and specific biological functions of these protrusions…
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Sortilin-related receptor is a druggable therapeutic target in breast cancer by Hussein Al-Akhrass et al.
In breast cancer, the currently approved anti-receptor tyrosine-protein kinase erbB-2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying…
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Myosin-X and talin modulate integrin activity at filopodia tips by Mitro Miihkinen et al.
Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we report that…
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Zebrafish Embryo Xenograft and Metastasis Assay by Ilkka Paatero et al.
Xenograft models, and in particular the mouse xenograft model, where human cancer cells are transplanted into immunocompromised mice, have been used extensively in cancer studies.…
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Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation by Alana R Cowell et al.
Talin is a mechanosensitive adapter protein that couples integrins to the cytoskeleton. Talin rod domain-containing protein 1 (TLNRD1) shares 22% homology with the talin R7R8…
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Integrin adhesion complexes by Megan R Chastney et al.
Tissue architecture and function are orchestrated by an intricate repertoire of cellular adhesion and signalling receptors, and by the surrounding extracellular matrix (ECM). The essential…
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Food for thought: How cell adhesion coordinates nutrient sensing by Hellyeh Hamidi et al.
Cell adhesion controls cell survival and proliferation via multiple mechanisms. Rabanal-Ruiz et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202004010) demonstrate that focal adhesions are key signaling hubs…
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