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Positive and negative durotaxis – mechanisms and emerging concepts by Mathilde Mathieu et al.
Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to…
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Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration by Michal Dibus et al.
Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and tissue integrity. In vivo, these processes are regulated by complex physicochemical signals from the extracellular…
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Focal adhesions contain three specialized actin nanoscale layers by Reena Kumari et al.
Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain…
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Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton by Amy E M Beedle et al.
The cell nucleus is continuously exposed to external signals, of both chemical and mechanical nature. To ensure proper cellular response, cells need to regulate not…
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Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration by Aleksi Isomursu et al.
Cells are highly dynamic and adopt variable shapes and sizes. These variations are biologically important but challenging to investigate in a spatiotemporally controlled manner. Micropatterning,…
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Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling by James R W Conway et al.
Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to provide tissue- and organ-specific cues,…
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IGFBP2 secretion by mammary adipocytes limits breast cancer invasion by James R W Conway et al.
The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a significantly poorer prognosis and is…
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Myosin-X recruits lamellipodin to filopodia tips by Ana Popović et al.
Myosin-X (MYO10), a molecular motor localizing to filopodia, is thought to transport various cargo to filopodia tips, modulating filopodia function. However, only a few MYO10…
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PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers by Anna Aakula et al.
While organ-confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance to anoikis, a form of cell…
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An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation by Katri Vaparanta et al.
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the…
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MYO10-filopodia support basement membranes at pre-invasive tumor boundaries by Emilia Peuhu et al.
Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the encapsulating DCIS basement membrane (BM) is compromised, and tumor cells…
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Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Paulina Moreno-Layseca et al.
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