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Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells by Ghaffar Muharram et al.
No abstract
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FiloQuant reveals increased filopodia density during breast cancer progression by Guillaume Jacquemet et al.
Defective filopodia formation is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive front, accompany cancer cell dissemination. Despite wide biological…
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Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation by Maria Georgiadou et al.
Integrin activation is essential for cell adhesion and for connecting the extracellular matrix to the actin cytoskeleton. Thus, inappropriate integrin activation has been linked to…
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A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion by Elisa Närvä et al.
Cell-type-specific functions and identity are tightly regulated by interactions between the cell cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) have ultimate…
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AMPK negatively regulates tensin-dependent integrin activity by Maria Georgiadou et al.
Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions…
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SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras by Johanna Lilja et al.
SHANK3, a synaptic scaffold protein and actin regulator, is widely expressed outside of the central nervous system with predominantly unknown function. Solving the structure of…
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Vascular Morphogenesis: An Integrin and Fibronectin Highway by Hellyeh Hamidi et al.
A new study shows that endothelial cells use synaptic-like machinery to control polarized secretion and deposition of newly synthesised fibronectin. This process is coupled to…
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Erratum: Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 by Nicola De Franceschi et al.
No abstract
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SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland by Emilia Peuhu et al.
SHARPIN is a widely expressed multifunctional protein implicated in cancer, inflammation, linear ubiquitination and integrin activity inhibition; however, its contribution to epithelial homeostasis remains poorly…
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L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling by Guillaume Jacquemet et al.
Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in driving cancer cell invasion. Using a high-throughput microscopic-based drug screen,…
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Fetal liver endothelium regulates the seeding of tissue-resident macrophages by Pia Rantakari et al.
Macrophages are required for normal embryogenesis, tissue homeostasis and immunity against microorganisms and tumours. Adult tissue-resident macrophages largely originate from long-lived, self-renewing embryonic precursors and…
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The complexity of integrins in cancer and new scopes for therapeutic targeting by Hellyeh Hamidi et al.
Cancer is a complex disease and progresses within a dynamically evolving extracellular matrix that controls virtually every aspect of the tumour and tumour-associated cells. Interactions…
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Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription by Riina Kaukonen et al.
Tissue homeostasis is dependent on the controlled localization of specific cell types and the correct composition of the extracellular stroma. While the role of the…
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Vimentin coordinates fibroblast proliferation and keratinocyte differentiation in wound healing via TGF-β-Slug signaling by Fang Cheng et al.
Vimentin has been shown to be involved in wound healing, but its functional contribution to this process is poorly understood. Here we describe a previously…
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Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes by Rachel Barrow-McGee et al.
No abstract
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Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes by Rachel Barrow-McGee et al.
Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK,…
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Endosomes: Emerging Platforms for Integrin-Mediated FAK Signalling by Jonna Alanko et al.
Integrins are vital cell adhesion receptors with the ability to transmit extracellular matrix (ECM) cues to intracellular signalling pathways. ECM-integrin signalling regulates various cellular functions…
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Regulation of Cell Migration and β1 Integrin Trafficking by the Endosomal Adaptor GGA3 by Colin D H Ratcliffe et al.
The integrin family of cell adhesion receptors link extracellular matrices to intracellular signaling pathways and the actin cytoskeleton; and regulate cell migration, proliferation and survival…
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Integrin “endoadhesome” signaling suppresses anoikis by Jonna Alanko et al.
No abstract
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Selective integrin endocytosis is driven by interactions between the integrin α-chain and AP2 by Nicola De Franceschi et al.
Integrins are heterodimeric cell-surface adhesion molecules comprising one of 18 possible α-chains and one of eight possible β-chains. They control a range of cell functions…
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