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A functional genetic screen reveals new regulators of β1-integrin activity by Teijo Pellinen et al.
β1 integrins constitute a large group of widely distributed adhesion receptors, which regulate the ability of cells to interact with their surroundings. This regulation of…
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Distinct recycling of active and inactive β1 integrins by Antti Arjonen et al.
Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell adhesion. Integrin…
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Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway by Nina Rintanen et al.
Collagen receptor integrins recycle between the plasma membrane and endosomes and facilitate formation and turnover of focal adhesions. In contrast, clustering of α2β1 integrin with…
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Filopodia and adhesion in cancer cell motility by Antti Arjonen et al.
Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of…
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