Platelets form hemostatic plugs to prevent blood loss, and they modulate immunity and inflammation in several ways. A key event during hemostasis is activation of integrin αIIbβ3 through direct interactions of the β3 cytoplasmic tail with talin and kindlin-3. Recently,…
Successful establishment of a new Center of Excellence from Academy of Finland !
Ivaska Lab looking forward to exciting 8 years with the BarrierForce Center of Excellence. The CoE, directed by Johanna Ivaska, was selected as one of 11 new Aacdemy of Finland Centers of Excellence (2022-2029).To find out more please visit the…
Successful funding of ERKKO grant application !
Excited to receive a 990 000 eur grant to study Cancer metastasis – new biological paradigms as drug targets from Jane and Aatod Erkko -foundation for 2022-2025…
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Paulina Moreno-Layseca et al.
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the clathrin- and dynamin-independent endocytic pathway (CLIC-GEEC, CG pathway) is considered a bulk internalization route for the fluid phase, glycosylated membrane proteins and…
SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling by Siiri I Salomaa et al.
Actin-rich cellular protrusions direct versatile biological processes from cancer cell invasion to dendritic spine development. The stability, morphology, and specific biological functions of these protrusions are regulated by crosstalk between three main signaling axes: integrins, actin regulators, and small guanosine…
Hanna is joining the lab !
We are delighted to have Hanna Parkkola in the lab! She is back to her roots in cell culture after momentarily venturing into the wild world of protein chemistry. Welcome back!…
Mitro Miikhinen defended his PhD thesis in September !
Thanks to Staffan Strömblad, the opponent of Mitro from University of Stockholm for the visit. It was a great time. Now Mitro is going to be fine, studying hardcore statistics! The best of luck!…
Sortilin-related receptor is a druggable therapeutic target in breast cancer by Hussein Al-Akhrass et al.
In breast cancer, the currently approved anti-receptor tyrosine-protein kinase erbB-2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2-related therapeutic targets could offer a means to overcome these resistance mechanisms. We have…
Myosin-X and talin modulate integrin activity at filopodia tips by Mitro Miihkinen et al.
Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we report that active integrins accumulate at the tip of myosin-X (MYO10)-positive filopodia, while inactive integrins are uniformly…
Paulina’s paper is accepted !!
Celebrating our recent publication in Nature Cell Biology and the associated Highlight written by Pat Caswell ! Thanks Pat !…