The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the effect of structural variation in the eJM domain of receptor tyrosine kinases (RTK) on downstream…
MYO10-filopodia support basement membranes at pre-invasive tumor boundaries by Emilia Peuhu et al.
Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the encapsulating DCIS basement membrane (BM) is compromised, and tumor cells invade the surrounding stroma. The mechanisms that regulate functional epithelial BMs in vivo are poorly…
Directed cell migration towards softer environments by Aleksi Isomursu et al.
How cells sense tissue stiffness to guide cell migration is a fundamental question in development, fibrosis and cancer. Although durotaxis-cell migration towards increasing substrate stiffness-is well established, it remains unknown whether individual cells can migrate towards softer environments. Here, using…
MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels by Elisa Närvä et al.
MASTL is a mitotic accelerator with an emerging role in breast cancer progression. However, the mechanisms behind its oncogenicity remain largely unknown. Here, we identify a previously unknown role and eminent expression of MASTL in stem cells. MASTL staining from…
Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates by Swetha Raghuraman et al.
A key behavior observed during morphogenesis, wound healing, and cancer invasion is that of collective and coordinated cellular motion. Hence, understanding the different aspects of such coordinated migration is fundamental for describing and treating cancer and other pathological defects. In…
Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC by Ana Kasirer-Friede et al.
Platelets form hemostatic plugs to prevent blood loss, and they modulate immunity and inflammation in several ways. A key event during hemostasis is activation of integrin αIIbβ3 through direct interactions of the β3 cytoplasmic tail with talin and kindlin-3. Recently,…
Successful establishment of a new Center of Excellence from Academy of Finland !
The Ivaska Lab is looking forward to an exciting 8 years with the BarrierForce Center of Excellence. The CoE, directed by Johanna Ivaska, was selected as one of 11 new Aacdemy of Finland Centers of Excellence (2022-2029).To find out more…
Successful funding of ERKKO grant application !
Excited to receive a 990 000 eur grant to study Cancer metastasis – new biological paradigms as drug targets from Jane and Aatod Erkko -foundation for 2022-2025…
Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Paulina Moreno-Layseca et al.
Spatially controlled, cargo-specific endocytosis is essential for development, tissue homeostasis and cancer invasion. Unlike cargo-specific clathrin-mediated endocytosis, the clathrin- and dynamin-independent endocytic pathway (CLIC-GEEC, CG pathway) is considered a bulk internalization route for the fluid phase, glycosylated membrane proteins and…