β1-integrins mediate cell-matrix interactions and their trafficking is important in the dynamic regulation of cell adhesion, migration and malignant processes, including cancer cell invasion. Here, we employ an RNAi screen to characterize regulators of integrin traffic and identify the association…
68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice by Riikka Siitonen et al.
Shank-associated RH domain-interacting protein (SHARPIN) is a cytosolic protein that plays a key role in activation of nuclear factor κ-light-chain enhancer of activated B cells and regulation of inflammation. Furthermore, SHARPIN controls integrin-dependent cell adhesion and migration in several normal…
Integrin signaling and mechanotransduction in regulation of somatic stem cells by Aleksi Isomursu et al.
Somatic stem cells are characterized by their capacity for self-renewal and differentiation, making them integral for normal tissue homeostasis. Different stem cell functions are strongly affected by the specialized microenvironment surrounding the cells. Consisting of soluble signaling factors, extracellular matrix…
Author Correction: Every step of the way: integrins in cancer progression and metastasis by Hellyeh Hamidi et al.
In the originally published article, pertuzumab was incorrectly described as an anti-PI3K therapy in the section ‘Integrins in anticancer therapy’. The sentence should read ‘In mouse mammary tumour models, increased collagen levels and increased β1 integrin and SRC activity have…
Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability by Guillaume Jacquemet et al.
Filopodia are adhesive cellular protrusions specialized in the detection of extracellular matrix (ECM)-derived cues. Although ECM engagement at focal adhesions is known to trigger the recruitment of hundreds of proteins (“adhesome”) to fine-tune cellular behavior, the components of the filopodia…
Integrin trafficking in cells and tissues by Paulina Moreno-Layseca et al.
Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking…
ProLIF – quantitative integrin protein-protein interactions and synergistic membrane effects on proteoliposomes by Nicola De Franceschi et al.
Integrin transmembrane receptors control a wide range of biological interactions by triggering the assembly of large multiprotein complexes at their cytoplasmic interface. Diverse methods have been used to investigate interactions between integrins and intracellular proteins, and predominantly include peptide-based pulldowns…
Every step of the way: integrins in cancer progression and metastasis by Hellyeh Hamidi et al.
Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health. Integrins are the main cellular adhesion receptors that through multifaceted roles as signalling molecules, mechanotransducers and key components of the cell migration machinery are implicated in…
Targeting β1-integrin inhibits vascular leakage in endotoxemia by Laura Hakanpaa et al.
Loss of endothelial integrity promotes capillary leakage in numerous diseases, including sepsis, but there are no effective therapies for preserving endothelial barrier function. Angiopoietin-2 (ANGPT2) is a context-dependent regulator of vascular leakage that signals via both endothelial TEK receptor tyrosine…