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Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling by Nicola De Franceschi et al.
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of…
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Integrin endosomal signalling suppresses anoikis by Jonna Alanko et al.
Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic…
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Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα by Ying Wang et al.
Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet…
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Filopodia in cell adhesion, 3D migration and cancer cell invasion by Guillaume Jacquemet et al.
This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both…
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Integrin bondage: filamin takes control by Nicola De Franceschi et al.
No abstract
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Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function by Reetta Virtakoivu et al.
Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control…
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Blocking integrin inactivation as an anti-angiogenic therapy by Pipsa Saharinen et al.
During angiogenesis, endothelial cell migration is coordinated by integrin-mediated contact with the extra-cellular matrix (ECM), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal…
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Johanna Ivaska: Finding opposing forces in integrins by Johanna Ivaska et al.
Ivaska has taken the road less traveled to show how integrin inactivation regulates cell migration and invasion.
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Integrin traffic – the update by Nicola De Franceschi et al.
Integrins are a family of transmembrane cell surface molecules that constitute the principal adhesion receptors for the extracellular matrix (ECM) and are indispensable for the…
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Endothelial destabilization by angiopoietin-2 via integrin β1 activation by Laura Hakanpaa et al.
Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via Tie2 activation. Angiopoietin-2 (Ang2) functions as a context-dependent…
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OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity by Marion Weber-Boyvat et al.
ORP3 is an R-Ras interacting oxysterol-binding protein homolog that regulates cell adhesion and is overexpressed in several cancers. We investigated here a novel function of…
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Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells by Ghaffar Muharram et al.
Inappropriate MET tyrosine kinase receptor signaling is detected in almost all types of human cancer and contributes to malignant growth and MET dependency via proliferative…
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Distinct c-Met activation mechanisms induce cell rounding or invasion through pathways involving integrins, RhoA and HIP1 by Anja Mai et al.
Many carcinomas have acquired oncogenic mechanisms for activating c-Met, including c-Met overexpression and excessive autocrine or paracrine stimulation with hepatocyte growth factor (HGF). However, the…
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An RNAi screen identifies KIF15 as a novel regulator of the endocytic trafficking of integrin by Anastasia Eskova et al.
α2β1 integrin is one of the most important collagen-binding receptors, and it has been implicated in numerous thrombotic and immune diseases. α2β1 integrin is a…
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Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis by Antti Arjonen et al.
Mutations of the tumor suppressor TP53 are present in many forms of human cancer and are associated with increased tumor cell invasion and metastasis. Several…
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SHARPIN regulates uropod detachment in migrating lymphocytes by Jeroen Pouwels et al.
SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and…
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Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion by Patricia Costa et al.
Cell invasion through extracellular matrix (ECM) is a hallmark of the metastatic cascade. Cancer cells require adhesion to surrounding tissues for efficient migration to occur,…
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A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin by Saara Hämälistö et al.
Recently, we demonstrated that integrin adhesion to the extracellular matrix at the cleavage furrow is essential for cytokinesis of adherent cells. Here, we report that…
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Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone by Mikko Ylilauri et al.
T-cell protein tyrosine phosphatase (TCPTP) is a ubiquitously expressed non-receptor protein tyrosine phosphatase. It is involved in the negative regulation of many cellular signaling pathways.…
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Integrin inactivators: balancing cellular functions in vitro and in vivo by Daniel Bouvard et al.
Integrins mediate cell-matrix and cell-cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated…
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