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Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis by Antti Arjonen et al.
Mutations of the tumor suppressor TP53 are present in many forms of human cancer and are associated with increased tumor cell invasion and metastasis. Several…
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SHARPIN regulates uropod detachment in migrating lymphocytes by Jeroen Pouwels et al.
SHARPIN-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization, and…
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Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion by Patricia Costa et al.
Cell invasion through extracellular matrix (ECM) is a hallmark of the metastatic cascade. Cancer cells require adhesion to surrounding tissues for efficient migration to occur,…
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A ZO-1/α5β1-integrin complex regulates cytokinesis downstream of PKCε in NCI-H460 cells plated on fibronectin by Saara Hämälistö et al.
Recently, we demonstrated that integrin adhesion to the extracellular matrix at the cleavage furrow is essential for cytokinesis of adherent cells. Here, we report that…
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Molecular mechanism of T-cell protein tyrosine phosphatase (TCPTP) activation by mitoxantrone by Mikko Ylilauri et al.
T-cell protein tyrosine phosphatase (TCPTP) is a ubiquitously expressed non-receptor protein tyrosine phosphatase. It is involved in the negative regulation of many cellular signaling pathways.…
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Integrin inactivators: balancing cellular functions in vitro and in vivo by Daniel Bouvard et al.
Integrins mediate cell-matrix and cell-cell interactions and integrate extracellular cues to the cytoskeleton and cellular signalling pathways. Integrin function on the cell surface is regulated…
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Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation by Gunilla Högnäs et al.
Aneuploidy, deviation from the normal chromosome number, and other chromosomal aberrations are commonly observed in cancer. Integrin-mediated adhesion and dynamic turnover of adhesion sites are…
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Identification of protein interactions involved in cellular signaling by Jukka Westermarck et al.
Protein-protein interactions drive biological processes. They are critical for all intra- and extracellular functions, and the technologies to analyze them are widely applied throughout the…
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Unanchoring integrins in focal adhesions by Johanna Ivaska et al.
Focal adhesions are large structures through which integrins and scaffold proteins link the actin cytoskeleton to the extracellular matrix. A detailed analysis of integrin dynamics…
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The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling by Chiara Sandri et al.
During developmental and tumor angiogenesis, semaphorins regulate blood vessel navigation by signaling through plexin receptors that inhibit the R-Ras subfamily of small GTPases. R-Ras is…
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Negative regulators of integrin activity by Jeroen Pouwels et al.
Integrins are heterodimeric transmembrane adhesion receptors composed of α- and β-subunits. They are ubiquitously expressed and have key roles in a number of important biological…
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Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer by Reetta Virtakoivu et al.
AKT1 and AKT2 kinases have been shown to play opposite roles in breast cancer migration and invasion. In this study, an RNA interference screen for…
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A functional genetic screen reveals new regulators of β1-integrin activity by Teijo Pellinen et al.
β1 integrins constitute a large group of widely distributed adhesion receptors, which regulate the ability of cells to interact with their surroundings. This regulation of…
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Distinct recycling of active and inactive β1 integrins by Antti Arjonen et al.
Integrin trafficking plays an important role in cellular motility and cytokinesis. Integrins undergo constant endo/exocytic shuttling to facilitate the dynamic regulation of cell adhesion. Integrin…
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Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway by Nina Rintanen et al.
Collagen receptor integrins recycle between the plasma membrane and endosomes and facilitate formation and turnover of focal adhesions. In contrast, clustering of α2β1 integrin with…
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Filopodia and adhesion in cancer cell motility by Antti Arjonen et al.
Slender bundled actin containing plasma membrane protrusions, called filopodia, are important for many essential cellular processes like cell adhesion, migration, angiogenesis and the formation of…
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