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Integrin activity in neuronal connectivity by Johanna Lilja et al.
The formation of correct synaptic structures and neuronal connections is paramount for normal brain development and a functioning adult brain. The integrin family of cell…
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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation by Pirita Pekkonen et al.
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.…
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Mitosis-Resistant Adhesions Provide Molecular Memory to Dividing Cells by Guillaume Jacquemet et al.
During mitosis, animal cells disassemble focal adhesions and round up while remaining attached to the substrata via actin cables and unknown adhesive structures. In this…
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Using xCELLigence RTCA Instrument to Measure Cell Adhesion by Hellyeh Hamidi et al.
Cell adhesion to neighbouring cells and to the underlying extracellular matrix (ECM) is a fundamental requirement for the existence of multicellular organisms. As such, the…
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Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration by Kasper J Mygind et al.
The transmembrane protease ADAM9 is frequently upregulated in human cancers, and it promotes tumour progression in mice. In vitro, ADAM9 regulates cancer cell adhesion and…
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Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment by Riina Kaukonen et al.
2D surfaces offer simple analysis of cells in culture, yet these often yield different cell morphologies and responses from those observed in vivo. Considerable effort…
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Epithelial vimentin plays a functional role in mammary gland development by Emilia Peuhu et al.
In the mammary gland, vimentin intermediate filaments are expressed in stromal cells and in basal epithelial cell populations, including gland-reconstituting mammary stem cells, with largely…
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Tensin-4-Dependent MET Stabilization Is Essential for Survival and Proliferation in Carcinoma Cells by Ghaffar Muharram et al.
No abstract
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FiloQuant reveals increased filopodia density during breast cancer progression by Guillaume Jacquemet et al.
Defective filopodia formation is linked to pathologies such as cancer, wherein actively protruding filopodia, at the invasive front, accompany cancer cell dissemination. Despite wide biological…
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Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation by Maria Georgiadou et al.
Integrin activation is essential for cell adhesion and for connecting the extracellular matrix to the actin cytoskeleton. Thus, inappropriate integrin activation has been linked to…
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A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion by Elisa Närvä et al.
Cell-type-specific functions and identity are tightly regulated by interactions between the cell cytoskeleton and the extracellular matrix (ECM). Human pluripotent stem cells (hPSCs) have ultimate…
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AMPK negatively regulates tensin-dependent integrin activity by Maria Georgiadou et al.
Tight regulation of integrin activity is paramount for dynamic cellular functions such as cell matrix adhesion and mechanotransduction. Integrin activation is achieved through intracellular interactions…
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