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AXL-TBK1 driven AKT3 activation promotes metastasis by Emily N Arner et al.
The receptor tyrosine kinase AXL promotes tumor progression, metastasis, and therapy resistance through the induction of epithelial-mesenchymal transition (EMT). Here, we found that activation of…
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Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer by Karolina Punovuori et al.
Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly…
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Restoring mechanophenotype reverts malignant properties of ECM-enriched vocal fold cancer by Jasmin Kaivola et al.
Increased extracellular matrix (ECM) and matrix stiffness promote solid tumor progression. However, mechanotransduction in cancers arising in mechanically active tissues remains underexplored. Here, we report…
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The role and regulation of integrins in cell migration and invasion by Megan R Chastney et al.
Integrin receptors are the main molecular link between cells and the extracellular matrix (ECM) as well as mediating cell-cell interactions. Integrin-ECM binding triggers the formation…
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SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers by Johanna Lilja et al.
The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the…
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TLNRD1 is a CCM complex component and regulates endothelial barrier integrity by Neil J Ball et al.
We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-bundling protein in vitro. Here, we report that TLNRD1 is expressed in the…
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Positive and negative durotaxis – mechanisms and emerging concepts by Mathilde Mathieu et al.
Cell migration is controlled by the coordinated action of cell adhesion, cytoskeletal dynamics, contractility and cell extrinsic cues. Integrins are the main adhesion receptors to…
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Novel tools to study cell-ECM interactions, cell adhesion dynamics and migration by Michal Dibus et al.
Integrin-mediated cell adhesion is essential for cell migration, mechanotransduction and tissue integrity. In vivo, these processes are regulated by complex physicochemical signals from the extracellular…
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Focal adhesions contain three specialized actin nanoscale layers by Reena Kumari et al.
Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain…
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Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton by Amy E M Beedle et al.
The cell nucleus is continuously exposed to external signals, of both chemical and mechanical nature. To ensure proper cellular response, cells need to regulate not…
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Dynamic Micropatterning Reveals Substrate-Dependent Differences in the Geometric Control of Cell Polarization and Migration by Aleksi Isomursu et al.
Cells are highly dynamic and adopt variable shapes and sizes. These variations are biologically important but challenging to investigate in a spatiotemporally controlled manner. Micropatterning,…
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Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling by James R W Conway et al.
Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing and signaling in response to altered microenvironmental conditions. In order to provide tissue- and organ-specific cues,…
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IGFBP2 secretion by mammary adipocytes limits breast cancer invasion by James R W Conway et al.
The progression of noninvasive ductal carcinoma in situ to invasive ductal carcinoma for patients with breast cancer results in a significantly poorer prognosis and is…
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Myosin-X recruits lamellipodin to filopodia tips by Ana Popović et al.
Myosin-X (MYO10), a molecular motor localizing to filopodia, is thought to transport various cargo to filopodia tips, modulating filopodia function. However, only a few MYO10…
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PP2A methylesterase PME-1 suppresses anoikis and is associated with therapy relapse of PTEN-deficient prostate cancers by Anna Aakula et al.
While organ-confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance to anoikis, a form of cell…
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An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation by Katri Vaparanta et al.
The ErbB4 receptor isoforms JM-a and JM-b differ within their extracellular juxtamembrane (eJM) domains. Here, ErbB4 isoforms are used as a model to address the…
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MYO10-filopodia support basement membranes at pre-invasive tumor boundaries by Emilia Peuhu et al.
Ductal carcinoma in situ (DCIS) is a pre-invasive stage of breast cancer. During invasion, the encapsulating DCIS basement membrane (BM) is compromised, and tumor cells…
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Publisher Correction: Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis by Paulina Moreno-Layseca et al.
No abstract
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Directed cell migration towards softer environments by Aleksi Isomursu et al.
How cells sense tissue stiffness to guide cell migration is a fundamental question in development, fibrosis and cancer. Although durotaxis-cell migration towards increasing substrate stiffness-is…
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MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels by Elisa Närvä et al.
MASTL is a mitotic accelerator with an emerging role in breast cancer progression. However, the mechanisms behind its oncogenicity remain largely unknown. Here, we identify…
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