Integrins are heterodimeric cell-surface adhesion molecules comprising one of 18 possible α-chains and one of eight possible β-chains. They control a range of cell functions in a matrix- and ligand-specific manner. Integrins can be internalized by clathrin-mediated endocytosis (CME) through…
Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling by Nicola De Franceschi et al.
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (LUBAC). However, it is currently unclear how regulation of…
Integrin endosomal signalling suppresses anoikis by Jonna Alanko et al.
Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell adhesion, signalling and survival. Although integrins are known to undergo continuous endo/exocytic traffic, the potential impact of endocytic traffic on integrin-induced signals is unknown. Here, we demonstrate…
Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα by Ying Wang et al.
Regulated turnover of integrin receptors is essential for cell adhesion and migration. Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, yet proteins required for the internalization of this pro-invasive integrin remain to be identified. Here, we…
Filopodia in cell adhesion, 3D migration and cancer cell invasion by Guillaume Jacquemet et al.
This review discusses recent advances in our understanding of the role filopodia and filopodia-like structures in cell adhesion and three dimensional (3D) cell migration both in vitro and in vivo. In particular, we focus on recent advances demonstrating that filopodia…
Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function by Reetta Virtakoivu et al.
Epithelial-mesenchymal transition (EMT) in cells is a developmental process adopted during tumorigenesis that promotes metastatic capacity. In this study, we advance understanding of EMT control in cancer cells with the description of a novel vimentin-ERK axis that regulates the transcriptional…
Blocking integrin inactivation as an anti-angiogenic therapy by Pipsa Saharinen et al.
During angiogenesis, endothelial cell migration is coordinated by integrin-mediated contact with the extra-cellular matrix (ECM), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal and plasma membrane reorganization. A recent paper by Vitorino et al (2015) defined a new…
Johanna Ivaska: Finding opposing forces in integrins by Johanna Ivaska et al.
Ivaska has taken the road less traveled to show how integrin inactivation regulates cell migration and invasion.
Integrin traffic – the update by Nicola De Franceschi et al.
Integrins are a family of transmembrane cell surface molecules that constitute the principal adhesion receptors for the extracellular matrix (ECM) and are indispensable for the existence of multicellular organisms. In vertebrates, 24 different integrin heterodimers exist with differing substrate specificity…