mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion by Michalis Gounis et al.

Dev Cell. 2025 Apr 7;60(7):979-981. doi: 10.1016/j.devcel.2025.03.006.

ABSTRACT

The PI3K/AKT/mTOR pathway is considered a key therapeutic target in triple-negative breast cancer (TNBC). In this issue of Developmental Cell, Remy et al. challenge this idea by demonstrating that mTORC1 inhibition activates TFEB, promoting MT1-MMP exocytosis, ECM degradation, and increased cell invasion, especially when combined with chemotherapy.

PMID:40199239 | DOI:10.1016/j.devcel.2025.03.006

   

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