Nat Cell Biol. 2019 Feb;21(2):122-132. doi: 10.1038/s41556-018-0223-z. Epub 2019 Jan 2.

ABSTRACT

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is accomplished primarily through the integrin family of cell-surface receptors. Integrins are internalized and enter the endocytic-exocytic pathway before being recycled back to the plasma membrane. The trafficking of this extensive protein family is regulated in multiple context-dependent ways to modulate integrin function in the cell. Here, we discuss recent advances in understanding the mechanisms and cellular roles of integrin endocytic trafficking.

PMID:30602723 | PMC:PMC6597357 | DOI:10.1038/s41556-018-0223-z