EMBO J. 2015 May 12;34(10):1293-5. doi: 10.15252/embj.201591504. Epub 2015 Mar 31.

ABSTRACT

During angiogenesis, endothelial cell migration is coordinated by integrin-mediated contact with the extra-cellular matrix (ECM), coupled with receptor tyrosine kinase signalling to regulate dynamic cytoskeletal and plasma membrane reorganization. A recent paper by Vitorino et al (2015) defined a new MAP4K4–moesin–talin–β1-integrin pathway that could be therapeutically exploited to suppress pathologic angiogenesis.

PMID:25828097 | PMC:PMC4491991 | DOI:10.15252/embj.201591504