In breast cancer, the currently approved anti-receptor tyrosine-protein kinase erbB-2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2-related therapeutic targets could offer a means to overcome these resistance mechanisms. We have…
Myosin-X and talin modulate integrin activity at filopodia tips by Mitro Miihkinen et al.
Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we report that active integrins accumulate at the tip of myosin-X (MYO10)-positive filopodia, while inactive integrins are uniformly…
Paulina’s paper is accepted !!
Celebrating our recent publication in Nature Cell Biology and the associated Highlight written by Pat Caswell ! Thanks Pat !…
Martina Lerche defended her PhD thesis in September – such a RUSH !
Warm thank to Patrick Caswell, her opponent from University of Manchester, for joining us in person. It was an amazing scientific discussion. Now Martina is fighting border guards to enter the US and join the lab of Clare Waterman! Good…