Publications

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Selected Recent publications

  • Moreno-Layseca P, Jäntti NZ, Godbole R, Sommer C, Jacquemet G, Al-Akhrass H, Conway JRW, Kronqvist P, Kallionpää RE,  Oliveira-Ferrer L, Cervero P, Linder S, Aepfelbacher M, Zauber H, Rae J, Parton RG, Disanza A, Scita G, Mayor S,  Selbach M, Veltel S & Ivaska J (2021) Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis. Nat. Cell Biol.  23, pages1073–1084 – Share link, Open access here !
  • Salomaa SI, Miihkinen M, Kremneva E, Ilkka Paatero I, Lilja J, Jacquemet G, Vuorio J, Antenucci L, Kogan K, Nia FH, Hollos P, Isomursu A, Vattulainen I, Coffey ET, Kreienkamp H-J, Lappalainen P and Ivaska J (2021) SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling. Current Biology S0960-9822(21)01262-8 PMID: 34610274
  • Al-Akhrass H, Pietilä M, Lilja J, Vesilahti E-M, Anttila JM,Haikala HM, Munne PM, Klefström J, Peuhu E, Ivaska J. (2021) Sortilin-related receptor is a druggable therapeutic target in breast cancer. Mol. Oncology. Online pub PMID: 34564954
  • Miihkinen M, Grönloh MLB, Popovic A, Vihinen H, Eija Jokitalo E, Goult BT, Ivaska J and Jacquemet G (2021) Myosin-X and talin modulate integrin activity at filopodia tips. Cell Report. vol 36, Issue 11, 109716. PMID: 34525374
  • Isomursu A, Keun-Young P, Hou J, Cheng B, Shamsan G, Fuller B, Kasim J, Mahmoodi MM, Lu TJ, Genin GM, Xu F, Lin M, Distefano M, Ivaska J, Odde DJ (2020) Negative durotaxis: cell movement toward softer environments. BioRxiv. doi: 10.1101/2020.10.27.357178.”
  • Al-Akhrass H, Conway JRW, Poulsen ASA, Paatero I, Kaivola J, Padzik A, Andersen OM, Ivaska J (2021) A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene. 40, pages1300–1317
  • Taskinen ME, Närvä E, Conway JRW, Hinojosa LS, Lilla S, Mai A, De Franceschi N, Elo LL, Grosse R, Zanivan S, Norman JC, Ivaska J (2020) MASTL promotes cell contractility and motility through kinase-independent signaling. J Cell Biol. 219(6):e201906204. PMID: 32311005
  • Lerche M, Elosegui-Artola A, Kechagia JZ, Guzmán C, Georgiadou M, Andreu I, Gullberg D, Roca-Cusachs P, Peuhu E, Ivaska J (2020) Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts. iScience. 23(3):100907. [Epub ahead of print]
  • Stubb A, Guzmán C, Närvä E, Aaron J, Chew TL, Saari M, Miihkinen M, Jacquemet G, Ivaska J (2019) Superresolution architecture of cornerstone focal adhesions in human pluripotent stem cells. Nat Commun. 10(1):4756. PMID:31628312
  • Pietilä M, Sahgal, P, Peuhu E, Jäntti, N.Z, Paatero I, Närvä E, Al-Akhrass H, Lilja J, Georgiadou M, Andersen O.M, Padzik A, Sihto H, Joensuu H, Blomqvist M, Saarinen I, Boström P, Taimen P and Ivaska J (2019) SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2.  Nat Commun. 10(1):2340. PMID:31138794
  • Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, Ivaska J (2019) Filopodome mapping identifies p130Cas as a mechanosensitive regulator of filopodia stability.  Curr Biol. 29, 1–15.  Link to article
  • Georgiadou M, Lilja J, Jacquemet G, Guzmán C, Rafaeva M, Alibert C, Yan Y, Sahgal P, Lerche M, Manneville JB, Mäkelä TP, Ivaska J (2017) AMPK negatively regulates tensin-dependent integrin activity. J Cell Biol 216(4):1107-1121. PMID:28289092
  • Lilja J, Zacharchenko T, Georgiadou M, Jacquemet G, Franceschi N, Peuhu E, Hamidi H, Pouwels J, Martens V, Nia FH, Beifuss M, Boeckers T, Kreienkamp HJ, Barsukov IL, Ivaska J (2017) SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras. Nat Cell Biol 19(4):292-305. PMID: 28263956
  • Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, Sihto H, Ventelä S, Elo L, Jokitalo E, Westermarck J, Kellokumpu-Lehtinen PL, Joensuu H, Grenman R, Ivaska J (2016) Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription.   Nat Commun 7:12237. PMID: 27488962
  • Alanko J, Mai A, Jacquemet G, Schauer K, Kaukonen R, Saari M, Goud B, Ivaska J (2015) Integrin endosomal signalling suppresses anoikis.  Nat Cell Biol 17(11):1412-21. PMID:26436690

Reviews, Tools, Protocols

  • Chastney MR, Conway JRW, Ivaska J. Integrin adhesion complexes. Curr Biol. 2021 May 24;31(10):R536-R542.
  • Stubb A, Laine RF, Miihkinen M, Hamidi H, Guzmán C, Henriques R, Jacquemet G, Ivaska J (2020) Fluctuation-Based Super-Resolution Traction Force Microscopy. Nano Lett. 20(4):2230-2245
  • Barber-Pérez N, Georgiadou M, Guzmán C, Isomursu A, Hamidi H, Ivaska J (2020) Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels. J Cell Sci. 133 (12): jcs242909
  • Kechagia J, Ivaska J* and Roca-Cusachs P* (2019) Integrins as biomechanical sensors of the microenvironment.  Nat Rev Mol Cell Biol 20(8):457-473 . PMID:31182865. *corresponding authors
  • Moreno-Layseca P, Icha J, Hamidi H, Ivaska J (2019) Integrin trafficking in cells and tissues.  Nat. Cell Biol.  21(2):122-132. PMID:30602723
  • Hamidi H, Ivaska J (2018) Every step of the way: integrins in cancer progression and metastasis.  Nature Reviews Cancer 18(9):533-548. PMID:30002479
  • De Franceschi N, Hamidi H, Alanko J, Sahgal P, Ivaska J (2015) Integrin traffic – the update.  J Cell Sci 128(5):839-852. PMID:25663697
  • Kaukonen R, Jacquemet G, Hamidi H, Ivaska J (2017) Cell-derived matrices for studying cell proliferation and directional migration in a complex 3D microenvironment.  Nat Protoc 12(11):2376-2390. PMID:29048422
  • Georgiadou M, Ivaska J (2017) Tensins: Bridging AMP-Activated Protein Kinase with Integrin Activation.  Trends Cell Biol  pii: S0962-8924(17)30103-4